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Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

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Published on: November 11, 2022

Injectable Multifunctional Composite Hydrogel as a Combination Therapy for Preventing Postsurgical Adhesion.

Ke Lv¹, Peng Lou¹, Shuyun Liu¹

¹Department of General Surgery and NHC Key Laboratory of Transplant Engineering and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

Small (Weinheim an Der Bergstrasse, Germany)

|August 31, 2023

Summary

This study developed an injectable hydrogel to prevent postsurgical adhesions (PA). The "all-in-one" therapy combines physical barriers with anti-inflammatory and anti-fibrotic agents for effective tissue repair.

Keywords:

fibrosis flammation postsurgical adhesion self-assembling peptide hydrogel

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Postsurgical adhesion (PA) is a prevalent complication impacting millions globally.
Existing barrier materials are inadequate against diverse pathological factors driving PA formation.
Chronic inflammation and fibrosis are key contributors to in vivo adhesion development.

Purpose of the Study:

To design an injectable, multifunctional composite hydrogel for preventing postsurgical adhesions.
To address the limitations of current barrier materials in treating complex PA pathology.
To create a combination therapy integrating physical separation with bioactive agent delivery.

Main Methods:

Fabrication of a composite hydrogel using a cationic self-assembling peptide (KLD2R) and mesenchymal stem cell-derived nanovesicles (MSC-NVs) loaded with TGF-β receptor inhibitor (TGF-βRi).
Evaluation of the hydrogel's multifunctional properties: physical barrier, antibacterial effects, and sustained release of anti-inflammatory and anti-fibrotic agents.
In vivo assessment of the hydrogel's efficacy in inhibiting inflammation, fibrosis, and adhesion formation.

Main Results:

The composite hydrogel demonstrated physical separation, antibacterial activity, and sustained release of therapeutic agents.
Effective inhibition of local inflammation, fibrosis, and postsurgical adhesion formation in vivo.
The hydrogel exhibited good biocompatibility and biodegradability within the biological environment.

Conclusions:

The developed "all-in-one" composite hydrogel serves as an effective combination therapy for preventing postsurgical adhesions.
This strategy offers a promising approach for designing advanced treatments for various tissue injuries.
The multifunctional hydrogel overcomes the limitations of single-action barrier materials in managing complex pathological processes.