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Mechanisms Involved in the Therapeutic Effect of Cannabinoid Compounds on Gliomas: A Review with Experimental
Hugo Fernandes Oliveira Pires1,2, Pablo Rayff da Silva1,2, Arthur Lins Dias1
1Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Introduction:
Brain tumors have high morbidity and mortality rates, accounting for 1.4% of all cancers. Gliomas are the most common primary brain tumors in adults. Currently, several therapeutic approaches are used; however, they are associated with side effects that affect patients'quality of life. Therefore, further studies are needed to develop novel therapeutic protocols with a more favorable side effect profile. In this context, cannabinoid compounds may serve as potential alternatives.
Objective:
This study aimed to review the key enzymatic targets involved in glioma pathophysiology and evaluate the potential interaction of these targets with four cannabinoid derivatives through molecular docking simulations.
Methods:
Molecular docking simulations were performed using four cannabinoid compounds and six molecular targets associated with glioma pathophysiology.
Results:
Encouraging interactions between the selected enzymes and glioma-related targets were observed, suggesting their potential activity through these pathways. In particular, cannabigerol showed promising interactions with epidermal growth factor receptors and phosphatidylinositol 3- kinase, while Δ-9-tetrahydrocannabinol showed remarkable interactions with telomerase reverse transcriptase.
Conclusion:
The evaluated compounds exhibited favorable interactions with the analyzed enzymatic targets, thus representing potential candidates for further in vitro and in vivo studies.
Insights
Cannabinoid compounds show promise for treating brain gliomas by interacting with key enzymes. Further research is recommended for these potential novel cancer therapies.
Area of Science:
- Neuro-oncology
- Pharmacology
- Computational Chemistry
Background:
- Brain tumors, particularly gliomas, present significant mortality and morbidity challenges.
- Current glioma treatments have limitations and adverse effects, necessitating novel therapeutic strategies.
- Cannabinoid compounds are emerging as potential alternatives for glioma treatment due to their therapeutic properties.
Conclusions:
- The studied cannabinoid compounds display favorable interactions with key enzymatic targets in glioma.
- These findings suggest that cannabinoids are promising candidates for future in vitro and in vivo glioma research.
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