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Updated: Jul 17, 2025
Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
Published on: August 31, 2016
Spatial transcriptomics of a giant pilomatricoma.
Apoorva T Patil1, Daniel D Bennett2, Jin Xu1
1Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Giant pilomatricomas (PMs), rare skin tumors, exhibit distinct molecular profiles. Spatial gene expression analysis revealed unique transcriptomic patterns within an 8cm giant PM, offering new insights into these benign adnexal tumors.
Area of Science:
- Dermatopathology
- Molecular Biology
- Oncology
Background:
- Pilomatricomas (PMs) are common benign skin tumors, frequently affecting the head and neck.
- Activating mutations in the beta-catenin (CTNNB1) gene are a hallmark of PMs.
- Giant PMs (>4cm) are a rare variant, with potential differences in molecular signaling compared to typical sizes.
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