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Updated: Jul 17, 2025

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Genetic variants in the complement system and their potential link in the aetiology of type 1 diabetes
Suna Onengut-Gumuscu1, Bobbie-Jo M Webb-Robertson2,3, Soumyadeep Sarkar2
1Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Abstract:
Type 1 diabetes is an autoimmune disease in which one's own immune system destroys insulin-secreting beta cells in the pancreas. This process results in life-long dependence on exogenous insulin for survival. Both genetic and environmental factors play a role in disease initiation, progression, and ultimate clinical diagnosis of type 1 diabetes. This review will provide background on the natural history of type 1 diabetes and the role of genetic factors involved in the complement system, as several recent studies have identified changes in levels of these proteins as the disease evolves from pre-clinical through to clinically apparent disease.
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