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Related Experiment Videos

Orgotein in equine navicular disease: a double blind study.

J R Coffman, J H Johnson, L G Tritschler

    Journal of the American Veterinary Medical Association
    |February 1, 1979
    PubMed
    Summary

    Orgotein treatment showed a statistically significant positive effect in horses with navicular disease. Three of seven treated horses improved, compared to none of the placebo group, indicating potential therapeutic benefits.

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    Area of Science:

    • Veterinary Medicine
    • Equine Orthopedics
    • Pharmacology

    Background:

    • Navicular disease is a common degenerative condition affecting the equine foot.
    • It causes significant lameness and pain in horses, impacting athletic performance.
    • Current treatment options for navicular disease have variable success rates.

    Purpose of the Study:

    • To evaluate the efficacy of orgotein as a treatment for navicular disease in horses.
    • To compare the therapeutic effects of orgotein against a placebo in a double-blind study.

    Main Methods:

    • A double-blind study was conducted on 14 horses diagnosed with navicular disease.
    • Horses were randomly assigned to receive either orgotein or a placebo via juxtabursal injection.
    • Clinical and radiographic evidence confirmed the diagnosis in all participants.

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    Main Results:

    • Three out of seven horses treated with orgotein showed a positive clinical response.
    • None of the seven horses receiving the placebo demonstrated improvement.
    • The observed difference in response rates between the orgotein and placebo groups was statistically significant (P < 0.05).

    Conclusions:

    • Orgotein demonstrated a statistically significant therapeutic effect in treating navicular disease in horses.
    • These findings suggest orgotein may be a viable treatment option for equine navicular disease.
    • Further research is warranted to explore optimal dosing and long-term outcomes.