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Orgotein in equine navicular disease: a double blind study.
Journal of the American Veterinary Medical Association
|February 1, 1979
Summary
Orgotein treatment showed a statistically significant positive effect in horses with navicular disease. Three of seven treated horses improved, compared to none of the placebo group, indicating potential therapeutic benefits.
Area of Science:
- Veterinary Medicine
- Equine Orthopedics
- Pharmacology
Background:
- Navicular disease is a common degenerative condition affecting the equine foot.
- It causes significant lameness and pain in horses, impacting athletic performance.
- Current treatment options for navicular disease have variable success rates.
Purpose of the Study:
- To evaluate the efficacy of orgotein as a treatment for navicular disease in horses.
- To compare the therapeutic effects of orgotein against a placebo in a double-blind study.
Main Methods:
- A double-blind study was conducted on 14 horses diagnosed with navicular disease.
- Horses were randomly assigned to receive either orgotein or a placebo via juxtabursal injection.
- Clinical and radiographic evidence confirmed the diagnosis in all participants.
Main Results:
- Three out of seven horses treated with orgotein showed a positive clinical response.
- None of the seven horses receiving the placebo demonstrated improvement.
- The observed difference in response rates between the orgotein and placebo groups was statistically significant (P < 0.05).
Conclusions:
- Orgotein demonstrated a statistically significant therapeutic effect in treating navicular disease in horses.
- These findings suggest orgotein may be a viable treatment option for equine navicular disease.
- Further research is warranted to explore optimal dosing and long-term outcomes.