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Retrospective observational study of changes in serum cytokines and adiponectin with continuous plasma exchange with

Yuya Suzuki1, Hajime Nakae1, Kasumi Satoh1

  • 1Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, Akita, Japan.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|August 31, 2023
PubMed

Insights

Continuous plasma exchange with dialysis (cPED) therapy shows promise for severe COVID-19 patients. This blood purification method may help manage elevated inflammatory cytokines like IL-6 and IL-18, improving patient outcomes.

Area of Science:

  • Critical care medicine
  • Nephrology
  • Immunology

Background:

  • Severe COVID-19 is linked to elevated inflammatory cytokines, including Interleukin-6 (IL-6) and Interleukin-18 (IL-18).
  • Blood purification therapies are explored for cytokine control in COVID-19, but evidence of efficacy is limited.
  • Plasma exchange with dialysis (PED) is a blood purification technique utilizing selective plasma exchange.

Purpose of the Study:

  • To investigate the efficacy of continuous plasma exchange with dialysis (cPED) over 48 hours in severe COVID-19 patients.
  • To assess the impact of cPED on key inflammatory markers and adiponectin levels.

Main Methods:

  • Retrospective study involving five patients with severe COVID-19.
  • Continuous cPED therapy administered for 48 hours.
  • Monitoring of IL-6, IL-18, and adiponectin (APN) levels before and after treatment.

Main Results:

  • No significant overall changes in IL-6 and IL-18 levels were observed.
  • A marked improvement in IL-6 and IL-18 was noted in patients with high baseline levels.
  • Adiponectin (APN), an anti-inflammatory agent, showed a significant increase post-cPED.

Conclusions:

  • Continuous cPED therapy may be an effective treatment strategy for managing severe COVID-19.
  • The therapy appears beneficial in normalizing elevated cytokine levels and enhancing anti-inflammatory markers.
Abstract

Keywords:
adipokinehypercytokinemiarespiratory failureselective plasma exchangesevere COVID-19

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