Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

492
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
492
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.6K
Bone Disorders01:29

Bone Disorders

3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

47
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
47
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HRD Score: A Promising Biomarker for Genomic Instability Evaluation for Targeted Treatments Among Pancreatic Cancer Patients.

Technology in cancer research & treatment·2026
Same author

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid-Induced Bone Loss.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Involvement of COX-2 in the Neurovascular Unit Damage Through Up-Regulating Calpain/PARP/NF-κB Inflammatory Signaling During Ischemic Stroke.

Neurochemical research·2026
Same author

P2Y12 Inhibitors and Mortality in Patients Hospitalized With Intracerebral Hemorrhage.

JAMA network open·2026
Same author

Broussonin A Attenuates Type 2 Diabetic Osteoporosis by Reactivating JAK2/STAT3 Signaling to Inhibit Ferroptosis in BMSCs.

Phytotherapy research : PTR·2026
Same author

BCAA metabolism promotes lung cancer tumorigenesis by enhancing cholesterol biosynthesis.

Cell reports·2026

Related Experiment Video

Updated: Jul 17, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

390

Association Between Autoimmune Diseases and Sarcopenia: A Two-Sample Mendelian Randomization Study.

Qing Su1, Chen Jin2, Yi Yang1

  • 1Department of Epidemiology and Biostatistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, People's Republic of China.

Clinical Epidemiology
|August 31, 2023
PubMed
Summary

Rheumatoid arthritis (RA) causally impacts appendicular lean mass (ALM) and grip strength. Inflammatory bowel disease (IBD) and type 1 diabetes (T1D) may negatively affect ALM, suggesting links between autoimmune diseases and sarcopenia.

Keywords:
Mendelian randomizationappendicular lean massautoimmune diseasegrip strengthrheumatoid arthritissarcopenia

More Related Videos

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

10.6K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K

Related Experiment Videos

Last Updated: Jul 17, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

390
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

10.6K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K

Area of Science:

  • Rheumatology
  • Genetics
  • Gerontology

Background:

  • Observational studies suggest a link between autoimmune diseases and sarcopenia.
  • Causal relationships between autoimmune diseases and sarcopenia remain unestablished.

Purpose of the Study:

  • To investigate the causal associations between overall and specific autoimmune diseases and sarcopenia-related traits using Mendelian randomization (MR).

Main Methods:

  • Utilized publicly available summary-level data for autoimmune diseases and sarcopenia traits.
  • Employed inverse-variance-weighted (IVW) method as the primary analysis, with sensitivity and replication analyses.
  • Assessed reverse causation using reverse MR analyses.

Main Results:

  • Rheumatoid arthritis (RA) showed a causal effect on reduced appendicular lean mass (ALM) and lower grip strength.
  • Inflammatory bowel disease (IBD) and type 1 diabetes (T1D) were causally negatively associated with ALM.
  • Other autoimmune diseases and overall autoimmune disease did not show significant associations with sarcopenia traits.

Conclusions:

  • RA is causally linked to decreased ALM and grip strength.
  • IBD and T1D may have a causal negative impact on ALM.
  • Findings highlight potential causal pathways between specific autoimmune conditions and sarcopenia.