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Biomedical Data Annotation: An OCT Imaging Case Study.

Matthew Anderson1, Salman Sadiq2, Muzammil Nahaboo Solim2

  • 1School of Computing, Newcastle University, Urban Sciences Building, Newcastle upon Tyne NE4 5TG, UK.

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Summary
This summary is machine-generated.

Annotation quality for diabetic macular edema (DME) on optical coherence tomography (OCT) scans varies with clinician experience. Multiple annotation sessions showed limited improvement in intraretinal fluid (IRF) biomarker accuracy.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Optical coherence tomography (OCT) is crucial for eye structure visualization and disease detection.
  • Deep learning models require extensive, high-quality annotated datasets for accurate OCT image analysis.
  • Clinical annotation bottlenecks necessitate exploring annotations from clinicians with varying experience levels.

Purpose of the Study:

  • To evaluate the quality of intraretinal fluid (IRF) biomarker annotations in diabetic macular edema (DME) on OCT B-scans.
  • To assess the impact of clinician experience on annotation quality.
  • To determine the effectiveness of multiple annotation sessions after expert training.

Main Methods:

  • Five clinicians with diverse experience levels annotated IRF biomarkers on OCT B-scans of DME patients.
  • Annotation quality was assessed based on accuracy and consistency.
  • The effect of multiple annotation sessions following expert-led training was evaluated.

Main Results:

  • Significant variance in annotation performance was observed among clinicians.
  • Annotation quality correlated positively with the clinician's experience in interpreting OCT images of DME.
  • Multiple annotation sessions demonstrated a limited positive impact on overall annotation quality.

Conclusions:

  • Clinician experience is a critical factor influencing the reliability of OCT image annotations for DME.
  • Relying on less experienced annotators may compromise data quality for deep learning models.
  • Standardized training and quality control measures are essential for improving annotation consistency in clinical AI development.