Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.

Proceedings of the National Academy of Sciences of the United States of America·2010

Same author

Safety evaluation of tea (Camellia sinensis (L.) O. Kuntze) flower extract: assessment of mutagenicity, and acute and subchronic toxicity in rats.

Journal of ethnopharmacology·2010

Same author

Influences of soil properties and leaching on nickel toxicity to barley root elongation.

Ecotoxicology and environmental safety·2010

Same author

Effects of CO2 insufflation on cerebrum during endoscopic thyroidectomy in a porcine model.

Surgical endoscopy·2010

Same author

Plants' use of different nitrogen forms in response to crude oil contamination.

Environmental pollution (Barking, Essex : 1987)·2010

Same author

Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis.

Journal of the neurological sciences·2010

Search research articles

Related Experiment Video

Updated: Jul 17, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

A weighted cranial diffusion-weighted imaging scale for Wilson's disease.

Shi-Jing Wang^1,2, Hao Geng^3,4, Si-Rui Cheng⁵

¹Graduate School, Anhui University of Chinese Medicine, Hefei, China.

Frontiers in Neuroscience

|August 31, 2023

Summary

A new weighted cranial MRI scale helps predict Wilson's disease (WD) patient outcomes. Higher scores indicate increased risk of deterioration and hospital readmission during de-copper therapy.

Keywords:

MRI Wilson disease clinical assessment neuroimaging rating scores

More Related Videos

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Experiment Videos

Last Updated: Jul 17, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

Neurology
Radiology
Medical Imaging

Background:

Wilson's disease (WD) is a genetic disorder causing copper accumulation.
Neurological symptoms in WD require accurate assessment tools.
Cranial magnetic resonance imaging (MRI), particularly diffusion-weighted imaging (DWI), shows acute brain injuries in WD.

Purpose of the Study:

To develop a weighted cranial DWI scale for assessing neurological symptoms in WD patients.
To correlate the developed scale with clinical outcomes, including deterioration and readmission rates.
To improve prognostic prediction and guide treatment management in WD.

Main Methods:

123 WD patients underwent 1.5 T-MRI.
An imaging score was calculated based on T1, T2, fluid-attenuation inversion recovery, and DWI sequences.
Consensus weighting was applied based on symptoms and treatment response.

Main Results:

DWI hyperintensity in the putamen predicted deterioration during de-copper therapy (OR=8.656).
DWI hyperintensity in the midbrain and corpus callosum predicted readmission (OR=3.818 and OR=2.654, respectively).
The consensus scoring system showed higher correlations with deterioration and readmission compared to the original system.

Conclusions:

The consensus semi-quantitative scoring system for cranial MRI improves prediction of WD patient outcomes.
This scale can guide medication, healthcare management, and prognosis prediction.
Each point increase in the score correlates with a 5.2% increase in exacerbation risk and a 4.3% increase in 6-month readmission risk.