Related Experiment Video
Updated: Jul 17, 2025
09:32
Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
7.2K
[Reunderstanding of atopic dermatitis in the elderly]
1Department of Dermatology, The Southwest Hospital of Army Medical University, Chongqing 400038.
Zhonghua Yi Xue Za Zhi
|August 31, 2023
Summary
Atopic dermatitis (AD) in the elderly presents unique challenges, often leading to misdiagnosis due to distinct clinical features and aging-related immune changes. Recognizing these differences is crucial for accurate diagnosis and personalized treatment strategies in older adults.
Area of Science:
- Dermatology
- Geriatrics
- Immunology
Context:
- Atopic dermatitis (AD) is a complex skin condition with varied presentations across age groups.
- Elderly individuals exhibit unique AD characteristics, increasing the risk of misdiagnosis and delayed treatment.
- Aging-related changes in skin barrier function and immune responses contribute to the onset of AD in older adults.
Purpose:
- To highlight the distinct clinical manifestations and diagnostic challenges of atopic dermatitis in the elderly population.
- To underscore the importance of considering age-specific factors in the diagnosis and management of elderly AD.
- To advocate for personalized treatment approaches tailored to the elderly AD patient's specific needs.
Summary:
- Elderly AD often presents with 'reverse' clinical characteristics and is frequently associated with Th1-type skin inflammation.
- Diagnosis relies on excluding other conditions, emphasizing the need for careful clinical evaluation in older patients.
- Treatment requires a personalized strategy, considering individual skin properties and co-existing medical conditions in the elderly.
Impact:
- Improved recognition and diagnosis of atopic dermatitis in the elderly, reducing misdiagnosis rates.
- Enhanced understanding of the pathophysiology of aging-related skin barrier and immune dysfunction in AD.
- Facilitation of tailored, effective treatment plans for elderly patients with atopic dermatitis, improving quality of life.
Related Concept Videos
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
01:23Skin Diseases and Disorders
3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
01:30Hypersensitivities
735
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
735
02:06Allergic Reactions
27.8K
Overview
27.8K
01:20Asthma: Pathogenesis and Management
442
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
442
01:12Renewal of Skin Epidermal Stem Cells
2.5K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.5K