Photo-induced 1,2-thiohydroxylation of maleimide involving disulfide and singlet oxygen
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Updated: Jul 17, 2025

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Tamanna Khandelia1, Subhendu Ghosh1, Pritishree Panigrahi1
1Department of Chemistry, Indian Institute of Technology Guwahati, 781039, Assam, India. patel@iitg.ac.in.
Abstract:
A visible light-driven di-functionalization of maleimide with disulfide and in situ-generated singlet oxygen offers selective 1,2-thiohydroxylation under additive-free conditions. Here the disulfide plays the dual role of photosensitizer and the coupling reagent. Notably, the hydroxyl functionality originates from the in situ generated singlet oxygen followed by HAT from H2O (moisture).
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