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Long COVID After Bamlanivimab Treatment
Teresa H Evering1, Carlee B Moser2, Nikolaus Jilg3
1Department of Medicine, Weill Cornell Medicine, New York, New York.
Long COVID affected 18% of outpatients treated with bamlanivimab, regardless of viral load. Early symptoms post-treatment and factors like smoking and female sex predicted long COVID development.
Area of Science:
- Infectious Diseases
- Immunology
- Public Health
Background:
- Limited prospective data exist on long COVID in outpatients treated for COVID-19.
- This study evaluates long COVID frequency and predictors following bamlanivimab therapy.
Purpose of the Study:
- To determine the incidence of long COVID in patients receiving bamlanivimab for COVID-19.
- To identify predictors associated with developing long COVID.
Main Methods:
- Analysis of data from the ACTIV-2/A5401 trial participants who received bamlanivimab.
- Long COVID defined as persistent symptoms at 24 weeks; regression models used for association analysis.
Main Results:
- Among 506 participants, 18% reported long COVID at 24 weeks.
- Predictors included smoking (aRR 2.41), female sex (aRR 1.91), non-Hispanic ethnicity (aRR 1.92), and early symptoms (aRR 2.70).
- Nasal SARS-CoV-2 RNA levels were not associated with long COVID.
Conclusions:
- Long COVID can occur despite early monoclonal antibody treatment.
- Smoking, female sex, and early post-treatment symptoms are significant predictors.
- Early intervention may be crucial as long COVID processes appear to begin early.
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