[Autologous bone implant for reconstructive surgery after decompressive craniectomy in children]
Zh B Semenova1, A I Salimon2, A M Korsunsky2
1Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russia.
Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko
|August 31, 2023
Summary
A novel method for storing and sterilizing autologous bone implants at -80°C with hydrogen peroxide plasma is safe and effective for pediatric skull defect closure, showing low infection and resorption rates.
Area of Science:
- Craniofacial surgery
- Biomaterials science
- Pediatric neurosurgery
Context:
- Post-traumatic skull defects require surgical reconstruction for optimal brain function recovery.
- Autologous bone grafts are the preferred choice for pediatric skull defect closure due to limited implant options.
- Effective storage and sterilization methods are crucial for the success of autologous bone implants.
Purpose:
- To present a novel method for the storage and sterilization of autologous bone implants for pediatric skull defect closure.
- To evaluate the safety and efficacy of this method through clinical application and mechanical property analysis.
- To assess the rates of infection and bone resorption following the use of treated autologous bone grafts.
Summary:
- A method involving storage at -80°C and sterilization via hydrogen peroxide plasma was applied to 79 pediatric patients undergoing skull defect closure.
- Post-sterilization mechanical analysis revealed increased compressive strength and decreased tensile strength, without compromising functional outcomes.
- The procedure resulted in a low incidence of early infectious complications (2.5%) and complete resorption requiring reoperation (10.1%).
Impact:
- The proposed storage and sterilization technique demonstrates a low risk of infection and resorption, making it a viable option for pediatric skull reconstruction.
- This method supports the safe and effective use of autologous bone in pediatric patients, enhancing surgical rehabilitation outcomes.
- Optimized preservation and sterilization of autologous bone grafts can improve the success rates of craniofacial reconstructive surgery in children.
