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Experience with abatacept in refractory lupus nephritis
Emma Calatayud1,2, Marco Montomoli3, Ana Ávila4,5,6
1Hospital Universitario Doctor Peset, Valencia, Spain. caem@alumni.uv.es.
Rheumatology International
|August 31, 2023
Summary
Abatacept may offer a safe rescue therapy for lupus nephritis patients with nephrotic proteinuria refractory to other treatments. These cases show complete remission without serious adverse events, suggesting its potential as a valuable option.
Area of Science:
- Nephrology
- Rheumatology
- Immunology
Background:
- Lupus nephritis significantly increases morbidity in systemic lupus erythematosus patients.
- Effective treatment is vital to prevent chronic kidney disease progression.
- Novel therapies are emerging, but biologics have shown mixed results in clinical trials.
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