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Holoprosencephaly (HPE) : case report and review of the literature
Watik Fedoua1, Harrad Mouna1, Said Hasana1
1Gynecology Department, University Hospital Center Ibn Rochd Casablanca, Casablanca, Morocco; CHU Ibn Rochd, Casablanca, Morocco.
Introduction:
Holoprosencephaly (HPE) is a complex brain malformation resulting from a medial cleavage defect of the prosencephalon into right and left hemispheres, occurring during early embryonic development.
Case Presentation:
We report an alobar holoprosencephaly diagnosed on imaging (obstetrical ultrasound) and revealed by a polymalformative syndrome in an 8-month-old infant.
Discussion:
Holoprosencephaly affects the forebrain and face, causing neurological manifestations and facial anomalies of varying severity. HPE is a cerebral midline anomaly.
Conclusion:
Its fetal prognosis is extremely guarded, particularly for the alobar form.
