Related Experiment Video
Updated: Jul 17, 2025

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
Published on: December 23, 2022
Mechanotransduction: Forcing a change in metabolism
Logan W Dawson1, Nicholas M Cronin1, Kris A DeMali1
1Department of Biochemistry and Molecular Biology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Abstract:
Epithelial and endothelial cells experience numerous mechanical cues throughout their lifetimes. Cells resist these forces by fortifying their cytoskeletal networks and adhesions. This reinforcement is energetically costly. Here we describe how these energetic demands are met. We focus on the response of epithelial and endothelial cells to mechanical cues, describe the energetic needs of epithelia and endothelia, and identify the mechanisms these cells employ to increase glycolysis, oxidative phosphorylation, and fatty acid metabolism. We discuss the similarities and differences in the responses of the two cell types.
Related Concept Videos
Regulation of Metabolism
Energy to Drive Translocation
Generally, polypeptides are unfolded by two distinct...
Chemiosmosis and ATP Synthesis
Introduction to Metabolism
Chemiosmosis
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons...
Mechanical Protein Functions

