Revisiting six established practices in the treatment of chronic myeloid leukaemia

After two decades of use in chronic myeloid leukaemia, the risks and benefits of established treatment practices for BCR::ABL1 tyrosine kinase inhibitors (TKIs) in the chronic myeloid leukaemia in chronic phase of the disease should be analysed. In this Viewpoint, we suggest that the use of lower than approved TKI doses in both front-line and later-line therapies would result in similar treatment efficacy, less toxicity, better treatment compliance, and reduced cost of care. The absence of an early molecular response might not warrant a change of a TKI, particularly for second-generation TKIs. Among patients in whom reaching a treatment-free remission is not a therapeutic goal or treatment-free remission is unlikely, changing TKIs to improve the depth of molecular response might result in more harm than good. Reducing the TKI dose in response to mild to moderate, or even serious, reversible side-effects might be better than changing the TKI. The availability of generic imatinib, generic dasatinib, and possibly later other generic second-generation TKIs would offer 90% of patients with chronic myeloid leukaemia an effective, safe, and affordable therapy that normalises life expectancy, and results in treatment-free remission status in 30-50% of patients over the long term. Finally, based on treatment value, any TKI that costs more than US$30 000-40 000 per year should be critically evaluated in relation to alternative modalities, such allogeneic haematopoietic stem-cell transplantation.