Intravaginal Mesalamine Administration: A Novel Technique for Neovaginal Colitis.

Area of Science:

• Gastroenterology
• Colorectal Surgery
• Gynecologic Surgery

Background:

• Neovaginal diversion colitis is a rare complication following colonic vaginoplasty.
• Management options for this condition are limited.

Observation:

• A 21-year-old cisgender female with VACTERL syndrome underwent colonic vaginoplasty in infancy.
• The patient developed symptoms consistent with neovaginal diversion colitis.

Findings:

• A novel treatment involving vaginal instillation of mesalamine was administered.
• Complete resolution of symptoms was achieved following this intervention.

Implications:

• This case study suggests vaginal mesalamine instillation as a potentially effective treatment for neovaginal diversion colitis.
• Further research is warranted to validate this therapeutic approach.