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Defining a Childhood Type 1 Diabetes Cohort, Clinical Practice Measures, and Outcomes Within Administrative Data in
Danya Fox1, Qian Zhang2, Nazrul Islam3
1Division of Endocrinology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Insights
Researchers created a cohort of nearly 6,000 individuals with childhood-onset type 1 diabetes (T1D) using administrative data. This cohort enables studying T1D clinical practice measures and their impact on health outcomes.
Area of Science:
- Endocrinology
- Public Health
- Data Science
Background:
- Childhood-onset type 1 diabetes (T1D) requires long-term management and monitoring.
- Administrative data offers a valuable resource for population-level health research.
- Defining clinical practice measures is crucial for assessing diabetes care quality.
Purpose of the Study:
- To establish a comprehensive administrative cohort of individuals with childhood-onset T1D in British Columbia.
- To define key clinical practice measures relevant to T1D management using administrative data.
Main Methods:
- Utilized linked administrative data from British Columbia spanning 1992-1993 to 2019-2020.
- Applied a validated diabetes case-finding definition and differentiating algorithm to identify eligible individuals.
- Defined clinical practice measures based on established clinical practice guidelines.
Main Results:
- An administrative cohort of 5,901 individuals with childhood-diagnosed T1D was established (April 1, 1996 - March 31, 2020).
- The cohort has a mean age of 22.31 years (SD 8.21).
- Key derived clinical practice measures include outpatient visits, HbA1c tests, and screenings for thyroid, retinopathy, and nephropathy.
Conclusions:
- An administrative cohort of approximately 6,000 individuals with childhood-onset T1D and over 20 years of follow-up data has been successfully created.
- This cohort provides a robust foundation for future research on the relationship between clinical practice measures and clinical outcomes in T1D.
Objective:
We used administrative data to 1) establish a cohort of individuals with childhood-onset type 1 diabetes (T1D) in British Columbia (BC), and 2) define T1D-related clinical practice measures.
Methods:
We applied a validated diabetes case-finding definition and differentiating algorithm to linked administrative data (1992-1993 to 2019-2020). Cases were removed when they did not meet inclusion criteria for childhood-onset T1D. Clinical practice measures were defined based on clinical practice guidelines.
Results:
We developed an administrative cohort that included 5,901 individuals with childhood-diagnosed T1D between April 1, 1996, and March 31, 2020. The mean age was 22.31 (standard deviation 8.21) years. Clinical practice measures derived included diabetes outpatient visits (N=4,935) and glycated hemoglobin tests (N=4,935), and screening for thyroid function (N=4,457), retinopathy (N=1,602), and nephropathy (N=2,369).
Conclusions:
We established an administrative cohort of ∼6,000 individuals with childhood-onset T1D with 20+ years of follow-up data that can be used to describe the association between clinical practice measures and clinical outcomes.
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