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Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
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Does exercise influence skeletal muscle by modulating mitochondrial functions via regulating MicroRNAs? A systematic
Yu-Feng Long1, Simon Kwoon-Ho Chow2, Can Cui1
1Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China.
Ageing Research Reviews
|August 31, 2023
Summary
Physical exercise can improve muscle mass and strength by regulating microRNAs that control mitochondrial function, offering new strategies to combat sarcopenia.
Area of Science:
- Muscle physiology and molecular biology.
- Gerontology and aging research.
- Mitochondrial biology and function.
Background:
- Sarcopenia, characterized by muscle loss, is linked to mitochondrial dysfunction.
- MicroRNAs play a critical role in regulating mitochondrial function.
- Understanding the molecular mechanisms of exercise interventions for sarcopenia is crucial.
Approach:
- A systematic literature search was conducted across PubMed, Embase, and Web of Science.
- Studies were identified using keywords related to microRNAs, mitochondria, muscle, and exercise.
- PRISMA guidelines were followed for study selection and data extraction.
Key Points:
- 18 preclinical and 5 clinical studies were reviewed.
- Physical exercise positively impacts mitochondrial function through microRNA regulation.
- Specific microRNAs were identified as either improving or suppressing mitochondrial function.
Conclusions:
- Physical exercise enhances muscle performance by up-regulating mitochondrial functions, including biogenesis.
- Modulation of microRNAs is a key mechanism through which exercise benefits muscle health.
- This review highlights the interconnectedness of exercise, mitochondrial function, and microRNAs in sarcopenia.
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