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Pediatric Traumatic Brain Injury: Impact on the Developing Brain.

Laura S Blackwell1, Robert Grell1

  • 1Department of Pediatrics, Emory University, Atlanta, Georgia.

Pediatric Neurology
|August 31, 2023
PubMed
Summary

Traumatic brain injury (TBI) in children and adolescents can disrupt developing brain networks, impacting neurocognitive outcomes. This review examines pediatric TBI, its developmental effects, and recovery factors.

Keywords:
DevelopmentalManagementNeurocognitiveNeuroplasticityOutcomesPediatricTraumatic brain injury

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Public Health

Background:

  • Traumatic brain injury (TBI) affects millions of children and adolescents annually.
  • Pediatric TBI poses a significant public health challenge due to its impact on critical developmental periods.
  • Brain development is vulnerable to injury, affecting neurocognitive functions.

Purpose of the Study:

  • To review the current literature on pediatric TBI.
  • To systematically examine the developmental aspects of TBI in children.
  • To highlight knowledge gaps in pediatric TBI research.

Main Methods:

  • Systematic literature review.
  • Focus on pathophysiology and developmental impact of pediatric TBI.
  • Analysis of pre- and post-injury factors influencing recovery.

Main Results:

  • Pediatric TBI disrupts the formation of brain networks crucial for neurocognitive development.
  • Developmental stage at injury significantly influences outcomes.
  • Pre- and post-injury factors modulate recovery trajectories.

Conclusions:

  • Understanding the developmental impact of TBI in children is critical.
  • Further research is needed to address knowledge gaps in pediatric TBI.
  • Targeted interventions considering developmental factors may improve outcomes.