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The stress-responsive protein REDD1 and its pathophysiological functions

Ji-Yoon Kim1, Young-Guen Kwon2, Young-Myeong Kim3

  • 1Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, Seoul, 04763, Republic of Korea.

Experimental & Molecular Medicine
|August 31, 2023
PubMed

Insights

Regulated in development and DNA damage-response 1 (REDD1) is a stress protein with dual roles in cellular functions and disease pathogenesis. Understanding REDD1

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Pathophysiology

Background:

  • Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced protein.
  • REDD1 influences critical cellular processes such as metabolism, autophagy, and cell fate.
  • It plays a role in the pathogenesis of diseases including cancer, metabolic disorders, and neurodegeneration.

Purpose of the Study:

  • To review and discuss the molecular mechanisms of REDD1 expression and action.
  • To elucidate the diverse biological functions of REDD1.
  • To highlight the pathophysiological roles of REDD1 in various diseases.

Main Methods:

  • Literature review of published studies on REDD1.
  • Analysis of REDD1's interaction partners and cellular localization.
  • Discussion of REDD1's regulation of mTORC1 signaling and NF-κB activation.

Main Results:

  • REDD1 exhibits context-dependent deleterious and protective functions.
  • Its effects are mediated through mTORC1-dependent or -independent pathways.
  • REDD1 interacts with proteins like 14-3-3, IκBα, and TXNIP/GRP75 to modulate cellular activities.

Conclusions:

  • The diverse functions of REDD1 are contingent on cell type, context, interactors, and localization.
  • A comprehensive understanding of REDD1's molecular mechanisms and roles is crucial for addressing associated diseases.
  • Further research into REDD1 is warranted for therapeutic targeting in various pathophysiological conditions.

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