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Causal Associations Between Gut Microbiota and Psoriasis: A Mendelian Randomization Study

Chenyang Zang1,2,3,4,5, Jie Liu5, Manyun Mao1,2,3,4

  • 1The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Dermatology and Therapy
|August 31, 2023
PubMed
Abstract

Insights

This study used Mendelian randomization to investigate the causal link between gut microbiota and psoriasis. The Eubacterium fissicatena group was identified as a risk factor for psoriasis, suggesting potential therapeutic targets.

Area of Science:

  • Microbiome research
  • Dermatology
  • Genetics

Background:

  • The gut-skin axis suggests a link between gut microbiota and psoriasis.
  • Existing evidence is heterogeneous, and causality is difficult to establish through observational studies.

Purpose of the Study:

  • To evaluate potential causal associations between gut microbiota (GM) and psoriasis.
  • To investigate the role of GM in psoriatic arthritis (PsA).

Main Methods:

  • Two-sample Mendelian randomization (MR) using large-scale GWAS summary datasets.
  • Inverse variance weighted (IVW) method as the primary analysis.
  • Sensitivity analyses including MR-Egger, weighted median, Cochrane's Q test, MR-Egger intercept test, MR-PRESSO, and leave-one-out analysis.

Main Results:

  • Nominal protective roles were found for Bacteroidetes and Prevotella in psoriasis.
  • Bacteroidia, Bacteroidales, and Ruminococcaceae UCG002 were nominally associated with lower PsA risk.
  • Pasteurellales, Pasteurellaceae, Blautia, Methanobrevibacter, and Eubacterium fissicatena group were nominally associated with increased PsA risk.
  • The E. fissicatena group was identified as a risk factor for psoriasis, even after FDR correction.

Conclusions:

  • Several nominal causal associations between gut microbiota and psoriasis/PsA were identified.
  • The E. fissicatena group is a confirmed risk factor for psoriasis.
  • These findings may offer novel therapeutic targets for psoriasis management.
Keywords:
Causal analysisGut microbiotaGut–skin axisMendelian randomizationPsoriasis

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