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Related Experiment Video

Updated: Jul 17, 2025

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Nerve Visualization using Phenoxazine-Based Near-Infrared Fluorophores to Guide Prostatectomy.

Lei G Wang1,2, Antonio R Montaño1, Anas M Masillati1

  • 1Biomedical Engineering Department, Oregon Health and Science University, Portland, OR, 97201, USA.

Advanced Materials (Deerfield Beach, Fla.)
|August 31, 2023
PubMed
Summary
This summary is machine-generated.

New near-infrared (NIR) fluorophores enable precise nerve identification during surgery. This molecular engineering approach integrates with existing systems, potentially reducing nerve injury in prostate cancer patients.

Keywords:
Biomaterialsclinical translationfluorescencefluorescence‐guided surgeryfluorophorenear‐infrared imagingnerve

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Area of Science:

  • Surgical innovation
  • Molecular imaging
  • Biomedical engineering

Background:

  • Fluorescence-guided surgery (FGS) utilizes near-infrared (NIR) fluorophores for enhanced visualization.
  • Current NIR systems lack tissue-specific contrast agents, hindering nerve identification during procedures like prostatectomy.
  • Identifying nerves is crucial to minimize morbidity in cancer patients.

Purpose of the Study:

  • To develop novel NIR fluorophores for intraoperative, nerve-specific imaging.
  • To create a library of phenoxazine-based fluorophores using drug-like molecular design.
  • To enable seamless integration into current surgical workflows.

Main Methods:

  • Synthesized a library of NIR phenoxazine-based fluorophores.
  • Employed drug-like molecular design principles.
  • Tested lead candidate fluorophore in preclinical models using the da Vinci Surgical System.

Main Results:

  • Successfully produced NIR phenoxazine-based fluorophores.
  • The lead candidate effectively delineated prostatic nerves in canines.
  • Demonstrated visualization of the iliac plexus in swine.
  • Confirmed compatibility with the da Vinci Surgical System.

Conclusions:

  • Molecular engineering of NIR nerve-binding fluorophores is feasible.
  • Developed fluorophores show potential for intraoperative nerve identification.
  • This approach facilitates clinical translation to reduce nerve injury during prostatectomy.