Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural changes in cryopreserved tracheal grafts of sprague-dawley rats.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2009
Same author

Facile synthesis of size-tunable micro-octahedra via metal-organic coordination.

Chemical communications (Cambridge, England)·2009
Same author

N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway.

Molecular carcinogenesis·2009
Same author

Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs.

Breast cancer research and treatment·2009
Same author

N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha.

Journal of cellular biochemistry·2009
Same author

A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo.

Cancer immunology, immunotherapy : CII·2009

Related Experiment Video

Updated: Jul 17, 2025

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.6K

Microfluidic Brain-on-a-Chip: From Key Technology to System Integration and Application.

Zhaohe Wang1, Yongqian Zhang1, Zhe Li1

  • 1School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.

Small (Weinheim an Der Bergstrasse, Germany)
|September 1, 2023
PubMed
Summary
This summary is machine-generated.

Brain-on-chip (BoC) models offer a powerful in vitro approach to study brain characteristics. This review categorizes BoCs into cell-, slice-, and organoid-based systems on microfluidic chips, detailing their technologies and future directions.

Keywords:
biomaterialsblood-brain barrierbrain organoidbrain-on-chipchip manufacturinginduced pluripotent stem cellmicrofluidic

More Related Videos

Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber
27:58

Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber

Published on: October 1, 2007

10.9K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.1K

Related Experiment Videos

Last Updated: Jul 17, 2025

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.6K
Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber
27:58

Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber

Published on: October 1, 2007

10.9K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.1K

Area of Science:

  • Neuroscience
  • Biotechnology
  • Microfluidics

Background:

  • Brain-on-chip (BoC) technology is a crucial in vitro model for understanding brain functions.
  • A universally accepted definition and scope for BoC models are currently lacking.
  • Microfluidic chips serve as essential platforms for advanced brain modeling.

Purpose of the Study:

  • To review and categorize existing brain-on-chip models.
  • To summarize core technologies, challenges, and future trends in BoC development.
  • To establish a clearer scope for brain-on-chip in vitro models.

Main Methods:

  • Classification of BoCs into three types: brain cells-on-a-chip, brain slices-on-a-chip, and brain organoids-on-a-chip.
  • Analysis of microfluidic chip applications in maintaining long-term culture activity.
  • Integration of cell biology, microenvironment technology, manufacturing, and online detection.

Main Results:

  • Microfluidic BoCs provide structural diversity and high compatibility for various experimental needs.
  • The reviewed BoC types utilize microfluidic chips as carriers for enhanced functionality.
  • Integration of multiple technologies enables advanced in vitro brain modeling.

Conclusions:

  • Brain-on-chip models, categorized by culture type, represent significant advancements in neuroscience research.
  • Microfluidic platforms are key to the success and longevity of these in vitro brain models.
  • Continued development in core technologies will expand the applications and potential of BoC systems.