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Updated: Jul 17, 2025
An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization
Published on: June 12, 2013
[Evolution of Research Related to Macrophage Polarization in Atherosclerosis:A Visualization Analysis]
Ju-Hong Pan1, Yue-Ying Chen1, Yu-Gang Hu1
1Department of Ultrasound Imaging,Renmin Hospital of Wuhan University,Wuhan 430060,China.
Abstract:
Objective To explore the research status,hotspots,and development tendency of macrophage polarization (MP) in atherosclerosis (AS) by systematically reviewing and visually analyzing the articles published recently in this field,so as to provide new ideas for the basic research and translational research on MP in the prevention and treatment of AS.Methods SCI-Expanded was used as the data source for the retrieval of the articles involving MP in AS from 2012 to 2022.CiteSpace 6.1.R3 was employed to visualize the node information of the publishing country/region,institutions,authors,keywords,and citations.Results A total of 381 papers were included.The number of publications in the world showed an increasing trend year by year.China and the United States were leading this field in the number and centrality of publications,and Shandong University in China contributed the largest number of publications.The analysis of the key words and citations showed that the hotspots and frontiers in this field mainly included the pathogenesis of AS,MP markers,macrophage plasticity regulation,and potential therapeutic targets for AS.Conclusions The research on MP in AS was booming during 2012-2022.The differential gene expression and the molecular mechanism of targeted therapy of MP in AS are the research trends in this field,which will provide new measures for the prevention and treatment of AS.
Insights
Research on macrophage polarization (MP) in atherosclerosis (AS) is rapidly growing. Key areas include MP markers, plasticity, and therapeutic targets for AS prevention and treatment.
Area of Science:
- Cardiovascular Research
- Immunology
- Biomedical Data Science
Context:
- Atherosclerosis (AS) remains a leading cause of cardiovascular disease.
- Macrophage polarization (MP) plays a critical role in AS pathogenesis.
- Understanding MP dynamics is crucial for developing novel therapeutic strategies.
Purpose:
- To systematically review and visualize the research landscape of macrophage polarization in atherosclerosis from 2012 to 2022.
- To identify current research hotspots, trends, and frontiers in MP and AS.
- To provide insights for future basic and translational research in AS prevention and treatment.
Summary:
- A bibliometric analysis of 381 papers published between 2012-2022 reveals a significant increase in research on macrophage polarization in atherosclerosis.
- China and the United States lead in publications, with Shandong University being a major contributor.
- Key research areas include AS pathogenesis, MP markers, macrophage plasticity, and therapeutic targets.
Impact:
- The study highlights the burgeoning field of MP in AS research.
- Future trends indicate a focus on differential gene expression and molecular mechanisms for targeted MP therapies.
- Findings offer potential new avenues for the prevention and treatment of atherosclerosis.
