Related Experiment Video

Updated: Jul 17, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

10.9K

Role of RIPK3‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases (Review)

Sheng Chen1, Senhong Guan1, Zhaohan Yan1

  • 1Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, Guangdong 528308, P.R. China.

International Journal of Molecular Medicine
|September 1, 2023
PubMed

Insights

Necroptosis, a cell death pathway, is implicated in cardiovascular diseases via the RIPK3-CaMKII-mPTP signaling pathway. This pathway

Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Cell Death Mechanisms

Background:

  • Necroptosis is a regulated form of cell death crucial for homeostasis and implicated in cardiovascular disease pathogenesis.
  • Key necroptosis mediators include Receptor Interacting Protein Kinase (RIPK) 1, RIPK3, and mixed lineage kinase domain-like protein.

Approach:

  • This review synthesizes current research on the RIPK3-CaMKII-mPTP signaling pathway in cardiovascular diseases.
  • It focuses on the role of this pathway in conditions like myocardial infarction, heart failure, and atherosclerosis.

Key Points:

  • Calcium/calmodulin-dependent protein kinase II (CaMKII) is a RIPK3 substrate that triggers mitochondrial permeability transition pore (mPTP) opening.
  • This RIPK3-CaMKII-mPTP axis mediates necroptosis in myocardial cells.
  • The pathway's involvement is explored across diverse cardiovascular pathologies and drug toxicities.

Conclusions:

  • The RIPK3-CaMKII-mPTP signaling pathway is a significant contributor to cardiovascular diseases.
  • Understanding this pathway offers potential therapeutic targets for treating various heart conditions and drug-induced cardiotoxicity.

Keywords:
CaMKIIRIPK3cardiovascular diseasesdrug targetmPTPnecroptosis

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