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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Platelet activation: a promoter for psoriasis and its comorbidity, cardiovascular disease

Ziqi Jiang1, Xiaoran Jiang2, Aijun Chen1

  • 1Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in Immunology
|September 1, 2023
PubMed

Insights

Platelet activation contributes to psoriasis and its associated cardiovascular disease (CVD). Understanding these mechanisms may improve CVD risk prediction and treatment for psoriasis patients.

Area of Science:

  • Dermatology
  • Immunology
  • Cardiology

Background:

  • Psoriasis is a chronic inflammatory skin disease linked to immune system dysregulation.
  • Psoriasis patients have a higher risk of developing cardiovascular disease (CVD).
  • Platelets are key in hemostasis and thromboinflammation, but their role in psoriasis and associated CVD is unclear.

Purpose of the Study:

  • To review evidence on platelet activation biomarkers and mechanisms in psoriasis.
  • To explore the role of platelet activation in psoriasis-associated CVD.
  • To discuss antiplatelet therapy implications for psoriasis and CVD prevention.

Main Methods:

  • Literature review of existing studies on platelet activation in psoriasis and CVD.
  • Analysis of biomarkers and pathophysiological mechanisms.
  • Discussion of therapeutic strategies involving antiplatelet agents.

Main Results:

  • Platelet activation is implicated in the pathophysiology of psoriasis.
  • Platelet activation contributes to the development of cardiovascular disease in psoriasis patients.
  • Antiplatelet therapies show potential for managing psoriasis and preventing associated CVD.

Conclusions:

  • Platelet activation is a significant factor in psoriasis and its cardiovascular complications.
  • Targeting platelet activation may offer novel therapeutic avenues.
  • Further research is needed to fully elucidate the role of platelets and optimize antiplatelet treatments.

Keywords:
cardiovascular diseasecytokinesendothelial cellleukocyteplateletpsoriasis

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