Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53

Area of Science:

• Pharmacology and Molecular Biology
• Cancer Research

Background:

• The mutant P53 protein is crucial in oral squamous cell carcinoma (OSCC) progression, influencing anti-apoptosis and drug resistance.
• Identifying novel therapeutic agents targeting mutant P53 is essential for effective OSCC treatment.

Purpose of the Study:

• To investigate the potential anti-cancer activities of bioactive compounds from C. cainito leaves.
• To identify novel inhibitors of the mutant P53 protein relevant to OSCC.

Main Methods:

• Mass spectrum analysis to identify bioactive compounds in C. cainito.
• Molecular docking simulations to assess P53 inhibitory potential of identified compounds.

Main Results:

• Pharmacologically significant bioactive compounds were identified in C. cainito for the first time.
• Four novel potential inhibitors of the P53 protein were identified through molecular docking.

Conclusions:

• C. cainito leaves contain compounds with potential anti-cancer properties.
• The identified compounds show promise as new P53 inhibitors for OSCC therapy.