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Updated: Jul 17, 2025

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
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Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography

Published on: November 1, 2024

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Association Between Helicobacter pylori Infection and Migraine: A Systematic Review

Sudiksha Sethia1, Tayyaba Batool1, Zarna Bambhroliya1

  • 1Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Cureus
|September 1, 2023
PubMed

Insights

This systematic review suggests a potential link between Helicobacter pylori infection and migraine, particularly in Asian populations. Further research is needed to understand the exact connection and underlying mechanisms.

Area of Science:

  • Neurology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Migraine is a widespread, debilitating neurological disorder.
  • The potential for chronic infectious causes of migraine remains underexplored.
  • Helicobacter pylori (H. pylori) is a common bacterial infection with known gastrointestinal effects.

Purpose of the Study:

  • To investigate the association between migraine and H. pylori infection.
  • To synthesize existing research on this potential link.
  • To identify gaps in current knowledge regarding H. pylori and migraine.

Main Methods:

  • Systematic literature search conducted across PubMed, Google Scholar, and Cochrane databases.
  • Adherence to Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.
  • Inclusion and exclusion criteria applied to select relevant studies, resulting in 10 articles.

Main Results:

  • Analysis of 10 studies (including RCTs, cohort, case-control, and meta-analysis) indicated a possible association.
  • The association between H. pylori infection and migraine appears more pronounced in Asian populations.
  • Current evidence suggests a potential link, but definitive conclusions require more investigation.

Conclusions:

  • A potential association exists between Helicobacter pylori infection and migraine.
  • The specific mechanisms driving this extra-gastric manifestation require further elucidation.
  • Additional research is warranted to confirm the link and explore causative pathways.
Keywords:
calcitonin gene-related peptide (cgrp)genetic variationheadache with aurahelicobacter pylorimigraine headaches

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