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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

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Management of diarrhea induced by EGFR-TKIs in advanced lung adenocarcinoma

Daniela Cárdenas-Fernández1, Pamela Soberanis Pina1, Jenny G Turcott1

  • 1Thoracic Oncology Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.

Therapeutic Advances in Medical Oncology
|September 1, 2023
PubMed

Insights

Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) treat lung cancer but often cause diarrhea. Dietary changes like increased fiber, glutamine, and probiotics may help manage this side effect, improving patient quality of life.

Area of Science:

  • Oncology
  • Pharmacology
  • Gastroenterology

Background:

  • Epidermal Growth Factor Receptor (EGFR) mutations drive lung adenocarcinoma, enabling targeted therapies.
  • EGFR-Tyrosine Kinase Inhibitors (TKIs) are crucial in personalized cancer medicine, inhibiting tumor cell proliferation and survival.
  • Diarrhea is a common and significant adverse event of EGFR-TKIs, impacting treatment adherence and patient quality of life.

Purpose of the Study:

  • To review the management of diarrhea associated with EGFR-TKIs.
  • To explore dietary interventions for mitigating EGFR-TKI-induced diarrhea.
  • To highlight the importance of managing diarrhea for patient outcomes and quality of life.

Main Methods:

  • Literature review on EGFR-TKI therapy and associated adverse events.
  • Analysis of studies investigating dietary modifications for diarrhea management.
  • Synthesis of evidence regarding the impact of diarrhea on treatment and quality of life.

Main Results:

  • EGFR-TKIs are effective targeted therapies but frequently cause diarrhea, affecting up to 95% of patients.
  • Severe diarrhea can lead to treatment interruptions, dose reductions, and diminished quality of life.
  • Dietary interventions including increased fiber, glutamine supplementation, and probiotics show potential in reducing diarrhea incidence.

Conclusions:

  • Effective management of EGFR-TKI-induced diarrhea is essential for maintaining treatment efficacy and patient well-being.
  • Dietary strategies may offer a beneficial approach to decrease the incidence and severity of diarrhea.
  • Improving diarrhea control can significantly enhance the quality of life for lung adenocarcinoma patients undergoing targeted therapy.
Keywords:
EGFRTKIdiarrhealung cancermanagement

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