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B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney

Nuria Dolade1,2, Sandra Rayego-Mateos1,2, Alicia Garcia-Carrasco1,2

  • 1Red de Investigación Renal (REDinREN), Ricords2040, Spain.

Clinical Science (London, England : 1979)
|September 1, 2023
PubMed

Insights

In chronic kidney disease (CKD), reduced B- and T-lymphocyte co-inhibitory molecule (BTLA) expression is linked to new atherosclerotic plaque development. This suggests BTLA may be a biomarker or therapeutic target for atherosclerosis in CKD patients.

Area of Science:

  • Nephrology
  • Immunology
  • Cardiovascular Medicine

Background:

  • Cardiovascular disease is a leading cause of mortality in chronic kidney disease (CKD) patients.
  • Atherosclerosis is accelerated in CKD, but specific risk factors remain unclear.

Purpose of the Study:

  • To identify novel CKD-related risk factors for atherosclerosis.
  • To investigate the role of immune response in CKD-accelerated atherosclerosis.

Main Methods:

  • mRNA array analysis of blood samples from CKD patients with and without new plaque development.
  • Validation of candidate mRNAs in a larger cohort.
  • In vivo and in vitro studies using experimental models of CKD-accelerated atherosclerosis and murine macrophages.

Main Results:

  • mRNA array identified significant differences in gene expression related to immune response.
  • Down-regulation of B- and T-lymphocyte co-inhibitory molecule (BTLA) was associated with new plaque development in CKD patients.
  • BTLA expression was decreased in CKD animal models, and uremic serum reduced BTLA expression in macrophages.

Conclusions:

  • BTLA down-regulation is a potential biomarker for atherosclerosis incidence in CKD.
  • BTLA represents a potential therapeutic target for managing atherosclerosis in CKD.
Abstract

Keywords:
Chronic Kidney diseaseatherosclerosisinflammation

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