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Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
Defining and Promoting Pediatric Pulmonary Health: Developing Biomarkers for Pulmonary Health
Michael D Davis1, Joe G Zein2, Silvia Carraro3
1Wells Center for Pediatric Research and Division of Pulmonology, Allergy, and Sleep Medicine, Riley Hospital for Children at Indiana University, Indianapolis, Indiana.
Insights
Early detection of childhood lung diseases is crucial. Advances in genetic testing and novel biomarkers can help identify and manage respiratory conditions before irreversible lung function loss occurs.
Area of Science:
- Pediatric Pulmonology
- Biomarker Discovery
- Respiratory Medicine
Background:
- Childhood respiratory disorders can lead to diminished lung function in adulthood.
- Current methods for early detection and disease progression assessment are insufficient.
- Advances offer potential for earlier intervention and prevention of lung damage.
Purpose of the Study:
- To summarize key discussions from the National Heart, Lung, and Blood Institute workshop on developing biomarkers for pediatric pulmonary health.
- To highlight advancements in identifying and assessing childhood lung diseases.
- To emphasize the importance of early detection and intervention.
Main Methods:
- Review of sessions from the 2021 Defining and Promoting Pediatric Pulmonary Health workshop.
- Discussion of genetic testing advancements.
- Exploration of novel diagnostic tools and biomarkers for pediatric lung diseases.
Main Results:
- Genetic assessments are improving disease detection.
- Low-cost diagnostics and minimally-invasive biomarkers show promise.
- Exhaled nitric oxide and novel biomarkers are being investigated for childhood lung diseases.
Conclusions:
- New biomarkers and diagnostic tools can aid in early detection and management of pediatric respiratory diseases.
- Proactive identification and monitoring can prevent long-term lung function decline.
- Continued research into biomarkers is essential for improving pediatric pulmonary health outcomes.
Abstract:
Children with inherited and/or acquired respiratory disorders often arrive in adolescence and adulthood with diminished lung function that might have been detected and prevented had better mechanisms been available to identify and to assess progression of disease. Fortunately, advances in genetic assessments, low-cost diagnostics, and minimally- invasive novel biomarkers are being developed to detect and to treat respiratory diseases before they give rise to loss of life or lung function. This paper summarizes the Developing Biomarkers for Pulmonary Health sessions of the National Heart, Lung, and Blood Institute- sponsored 2021 Defining and Promoting Pediatric Pulmonary Health workshop. These sessions discussed genetic testing, pulse oximetry, exhaled nitric oxide, and novel biomarkers related to childhood lung diseases.
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