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Rational design of small-molecule responsive protein switches

Sailan Shui1,2, Stephen Buckley1,2, Leo Scheller1,2

  • 1Laboratory of Protein Design and Immunoengineering (LPDI), STI, EPFL, Lausanne, Switzerland.

Protein Science : a Publication of the Protein Society
|September 1, 2023
PubMed
Summary

Small-molecule protein switches offer precise control over cellular functions. Advances in computational design are expanding their capabilities for synthetic biology, biotechnology, and medicine.

Keywords:
computational protein designprotein switchesprotein-ligand interactionsprotein-protein interactionssmall moleculesynthetic biology

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