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Updated: Jul 17, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Virus hijacking of host epigenetic machinery to impair immune response
Maëlle Locatelli1, Suzanne Faure-Dupuy2
1Department of Biology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina, USA.
Abstract:
Epigenetic modifications, such as DNA hypermethylation, histone acetylation/methylation, or nucleosome positioning, result in differential gene expression. These modifications can have an impact on various pathways, including host antiviral immune responses. In this review, we summarize the current understanding of epigenetic modifications induced by viruses to counteract host antiviral immune responses, which are crucial for establishing and maintaining infection of viruses. Finally, we provide insights into the potential use of epigenetic modulators in combating viral infections and virus-induced diseases.
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