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[Diagnostic value of various tuberculin preparations]
Zeitschrift Fur Erkrankungen Der Atmungsorgane
|January 1, 1986
Summary
Tuberculin testing remains crucial for tuberculosis diagnosis. Higher antigen concentrations in tuberculin preparations, like PPD 7.5 TU, reduce false negatives and improve diagnostic value, supporting the development of new national standards.
Area of Science:
- Immunology
- Infectious Diseases
- Public Health
Background:
- Tuberculosis (TB) diagnosis relies on tuberculin testing, even with declining incidence in developed nations.
- Previous studies revealed diagnostic value differences among various tuberculin preparations compared to RT 23.
- The Hungarian PPD-5 TU (HU 5 TU) and RT 23 showed the lowest rates of negative reactions in confirmed TB cases.
Purpose of the Study:
- To compare the biologic equivalence of different tuberculin preparations.
- To evaluate the impact of antigen concentration and Tween addition on tuberculin skin test reactions.
- To assess the rate of false negative reactions with varying tuberculin preparations and concentrations.
Main Methods:
- Investigated 400 cases of active, bacteriologically confirmed tuberculosis.
- Compared RT 23, HU 5 TU, PPD Dessau 2 TU, PPD Dessau 5 TU (with/without Tween), and PPD 7.5 TU (without Tween).
- Analyzed reaction sizes and rates of false negatives.
Main Results:
- Increasing antigen concentration to 5 TU or 7.5 TU slightly increased smaller reactions (6-10 mm) but not larger ones (>20 mm).
- The PPD 7.5 TU preparation demonstrated a decreased rate of false negative reactions.
- HU 5 TU and RT 23 exhibited the lowest rates of negative skin reactions in TB patients.
Conclusions:
- Higher antigen concentrations in tuberculin preparations can enhance diagnostic sensitivity.
- The PPD 7.5 TU preparation shows promise for reducing false negatives in TB diagnosis.
- Recommendations include developing a national tuberculin preparation with higher antigen concentration, biologically equivalent to RT 23 or HU 5 TU.
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