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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

154
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
154
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

333
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
333
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

229
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
229
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

322
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
322
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

565
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
565
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

293
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
293

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Solid-state analysis for pharmaceuticals: Pathways to feasible and meaningful analysis.

Jukka Rantanen1, Thomas Rades1, Clare Strachan2

  • 1Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Journal of Pharmaceutical and Biomedical Analysis
|September 1, 2023
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Summary

Pharmaceutical solid-state analysis is crucial for product design. This paper analyzes challenges and offers suggestions for effective solid-state analytical methods in drug development.

Keywords:
Analytical techniquesDosage formProcess analyticsProduct performanceSample preparationSolid-state properties

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Area of Science:

  • Pharmaceutical Science
  • Materials Science

Background:

  • Solid-state forms are preferred for pharmaceutical products due to patient preference and ease of manufacturing.
  • Solid form diversity is a key factor in pharmaceutical product design.
  • Effective solid-state analytical methods are essential for ensuring product quality and performance.

Purpose of the Study:

  • To critically analyze the challenges associated with solid-state analytics in the pharmaceutical industry.
  • To provide considerations and suggestions for implementing feasible and meaningful pharmaceutical analyses of solid-state forms.

Main Methods:

  • Literature review and critical analysis of existing solid-state analytical techniques.
  • Discussion of challenges in pharmaceutical solid-state characterization.
  • Synthesis of recommendations for future analytical strategies.

Main Results:

  • Identified key challenges in solid-state analytics, including polymorphism, amorphous content, and process control.
  • Highlighted the need for advanced analytical techniques to characterize complex solid forms.
  • Emphasized the importance of method validation and data interpretation.

Conclusions:

  • Solid-state characterization is vital for pharmaceutical development and quality control.
  • Addressing analytical challenges requires a combination of established and novel techniques.
  • Strategic implementation of solid-state analytics ensures robust drug product design and performance.