Research progress of sensors based on molecularly imprinted polymers in analytical and biomedical analysis

Molecularly imprinted polymers (MIPs) have had tremendous impact on biomimetic recognition due to their precise specificity and high affinity comparable to that of antibodies, which has shown the great advantages of easy preparation, good stability and low cost. The combination of MIPs with other analytical technologies can not only achieve rapid extraction and sensitive detection of target compounds, improving the level of analysis, but also achieve precise targeted delivery, in-vivo imaging and other applications. Among them, the recognition mechanism plays a vital role in chemical and biological sensing, while the improvement of the recognition element, such as the addition of new nanomaterials, can greatly improve the analytical performance of the sensor, especially in terms of selectivity. Currently, due to the need for rapid diagnosis and improved sensing properties (such as selectivity, stability, and cost-effectiveness), researchers are investigating new recognition elements and their combinations to improve the recognition capabilities of chemical sensing and bio-sensing. Therefore, this review mainly discusses the design strategies of optical sensors, electrochemical sensors and photoelectric sensors with molecular imprinting technology and their applications in environmental systems, food fields, drug detection and biology including bacteria and viruses.