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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

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CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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[Vasculitis oft the skin after cocaine use].

Rubi Stephani Hellwege1, Thomas Sitter2, Markus Wörnle3

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Deutsche Medizinische Wochenschrift (1946)
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Cocaine use can lead to a severe skin condition called vasculitis, characterized by painful purpura and necrotizing lesions. Prompt treatment with steroids and abstinence from cocaine resulted in symptom improvement.

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Area of Science:

  • Dermatology
  • Toxicology
  • Rheumatology

Context:

  • Cocaine use is associated with various systemic complications.
  • Cutaneous manifestations of drug abuse require thorough investigation.

Purpose:

  • To report a case of cocaine-induced vasculitis.
  • To highlight the clinical presentation, diagnosis, and management of this condition.

Summary:

  • A young adult presented with severe, painful skin lesions including purpura, necrosis, and blisters, particularly on the extremities.
  • Laboratory findings revealed elevated inflammatory markers and increased anti-neutrophil cytoplasmic antibodies (ANCA), specifically proteinase 3-ANCA and myeloperoxidase-ANCA.
  • The diagnosis of skin vasculitis secondary to cocaine use was established based on clinical and laboratory findings.

Impact:

  • This case underscores that vasculitis is a serious potential complication of recreational cocaine consumption.
  • Early recognition and intervention, including drug cessation and appropriate medical therapy, are crucial for managing cocaine-induced vasculitis.