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Prostatic Artery Embolization Using Polyethylene Glycol Microspheres: A 1-Year Follow-up Prospective Study Including

Bruna Ferreira Pilan¹, André Moreira de Assis¹, Airton Mota Moreira¹

¹Department of Radiology and Oncology, University of São Paulo Medical School, São Paulo, Brazil.

Journal of Vascular and Interventional Radiology : JVIR

|September 1, 2023

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Prostatic artery embolization (PAE) with polyethylene glycol (PEG) microspheres effectively improved symptoms for most benign prostatic hyperplasia (BPH) patients. While generally safe, urinary infections and prostatic tissue elimination occurred more frequently than with other embolics.

Area of Science:

Interventional Radiology
Urology

Background:

Benign prostatic hyperplasia (BPH) significantly impacts quality of life.
Prostatic artery embolization (PAE) is an emerging treatment for BPH.

Purpose of the Study:

To assess the safety and efficacy of PAE using polyethylene glycol (PEG) microspheres for moderate-to-severe BPH.

Main Methods:

A prospective study involving 30 BPH patients undergoing PAE with 400-μm PEG microspheres.
Evaluated outcomes included International Prostate Symptom Score (IPSS), quality of life (QoL), PSA, Qmax, PVR, and prostate volume (PV) at baseline and 3/12 months.

Main Results:

93.3% of patients showed significant and durable improvement in lower urinary tract symptoms (LUTSs).
Statistically significant improvements were observed in IPSS, QoL, Qmax, PSA, PVR, and PV at 12 months.

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No major adverse events occurred; minor events included urinary tract infection and prostatic tissue elimination.

Conclusions:

PAE with PEG microspheres demonstrates effectiveness in improving BPH symptoms up to 12 months.
Higher incidences of urinary infection and prostatic tissue elimination were noted compared to other embolic agents.