[Multicenter reticulohistiocytosis--histologic photoreport]

Histomorphologic features of multicentric reticulohistiocytosis are rarely seen in three predominant areas of one patient. Characteristic are infiltrates of eosinophilic histiocytes and multinuclear giant cells with opalescent appearance, fine vacuoles, and PAS-positive granules. In all three lesions, the histologic findings were identical. In the mucous membrane and the synovia, we found dilated vessels with thickened walls and edema of the tissue. In the synovia, size and number of the multinuclear giant cells are less pronounced.