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Strain-level structure of gut microbiome showed potential association with cognitive function in major depressive

Zaiquan Dong1, Qinglian Xie2, Yanling Yuan3

  • 1Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, PR China; Department of Psychiatry and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, PR China.

Journal of Affective Disorders
|September 1, 2023
PubMed
Abstract

Insights

Gut bacteria composition differs in major depressive disorder (MDD) patients, with specific strains correlating to cognitive function deficits. This suggests a link between the gut microbiome and MDD-related cognitive impairment.

Area of Science:

  • Microbiome Research
  • Neuroscience
  • Psychiatry

Background:

  • The gut microbiota's role in major depressive disorder (MDD) pathogenesis is established.
  • The impact of gut microbiota on cognitive function in MDD patients remains unclear.

Approach:

  • Employed 16S rRNA gene sequencing and shotgun metagenomic sequencing to analyze gut microbial composition in 57 MDD patients and 30 healthy controls (HCs).
  • Conducted strain-level meta-analysis to identify specific bacterial strains associated with MDD.
  • Correlated microbial findings with cognitive function tests, including the Stroop test.

Key Points:

  • Gut microbiota richness and diversity were similar between MDD patients and HCs.
  • Significant differences in the abundance of Bifidobacterium and Blautia were observed.
  • Specific bacterial strains (bin_31, bin_32, bin_55) showed significant associations with cognitive performance metrics.

Conclusions:

  • Gut microbiota composition, particularly at the strain level, may influence cognitive function in MDD.
  • Findings suggest a potential role for the gut microbiome in the pathogenesis and cognitive aspects of MDD.
Keywords:
16S rRNA gene sequencing analysisNeurocognitionShotgun metagenomic sequencingStrainStroop color-word test

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