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Updated: Jul 17, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Published on: July 17, 2019

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Multiple functions and dual characteristics of RAB11A in cancers

Rui-Jian Guo1, Yu-Fei Cao1, En-Min Li1

  • 1The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, Guangdong, PR China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|September 1, 2023
PubMed

Insights

Ras-related protein in brain 11A (RAB11A) is vital for vesicle trafficking and cancer progression. This review details RAB11A

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Cancer Research

Background:

  • Vesicle trafficking is crucial for cellular transport and signaling.
  • Ras-related protein in brain 11A (RAB11A) is a key regulator of vesicle trafficking.
  • Altered RAB11A expression is linked to various cancers, indicating its role in tumorigenesis.

Purpose of the Study:

  • To review and discuss the multifaceted roles of RAB11A in diverse biological processes.
  • To explore the regulatory mechanisms of RAB11A in different cancer types.
  • To highlight the dual oncogenic and tumor-suppressive functions of RAB11A in cancer.

Main Methods:

  • Literature review and synthesis of recent studies on RAB11A.
  • Analysis of RAB11A's involvement in endocytic recycling, receptor trafficking, exosome secretion, and cytokinesis.
  • Examination of RAB11A's regulatory roles and expression patterns in various tumor types.

Main Results:

  • RAB11A regulates key cellular processes including recycling, secretion, and cell division.
  • RAB11A exhibits context-dependent roles in cancer, acting as both an oncogene and a tumor suppressor.
  • Specific regulatory mechanisms of RAB11A in different cancers have been identified.

Conclusions:

  • RAB11A is a significant player in vesicle trafficking with implications for cancer development.
  • Understanding RAB11A's dual functions is critical for developing targeted cancer therapies.
  • Further research into RAB11A's molecular mechanisms and clinical significance is warranted.
Keywords:
CancerCytokinesisEndocytic recyclingExosome secretionPhagophore formationRAB11A

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