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Updated: Jul 17, 2025

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
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Biological function, regulatory mechanism, and clinical application of mannose in cancer

Haoyi Jin1, Xi Liu2, Hong-Xu Liu3

  • 1Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, 110042, Liaoning, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|September 1, 2023
PubMed

Insights

Mannose, a sugar, shows direct anticancer effects and enhances cancer treatments. It is also explored as a cancer biomarker and in drug delivery systems.

Area of Science:

  • Biochemistry
  • Oncology
  • Metabolomics

Background:

  • Monosaccharides beyond glucose are understudied in cancer.
  • Mannose plays a key role in protein glycosylation.
  • Emerging evidence suggests mannose has anticancer properties.

Purpose of the Study:

  • To review the regulatory roles of mannose in cancer.
  • To elucidate the mechanisms of mannose's anticancer effects.
  • To discuss mannose's applications in cancer diagnosis and therapy.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of mannose's biochemical functions in cancer cells.
  • Examination of mannose's role in enhancing existing cancer treatments.

Main Results:

  • Mannose exhibits direct anticancer activity in vitro and in vivo.
  • Mannose potentiates chemotherapy, radiotherapy, targeted therapy, and immunotherapy.
  • Mannose serves as a potential cancer biomarker and in drug delivery systems.

Conclusions:

  • Mannose has significant therapeutic potential in oncology.
  • Further research into mannose's mechanisms and applications is warranted.
  • Mannose represents a promising area for cancer treatment and diagnosis.
Keywords:
BiomarkersCancer treatmentDrug delivery systemsMannoseSignal transduction

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