Related Experiment Video

Updated: Jul 17, 2025

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

33.6K

Interferon signaling restrains renal cell carcinoma heterogeneity

Peter Holicek1, Jitka Fucikova1, Lorenzo Galluzzi2

  • 1Sotio Biotech a.s., Prague, Czech Republic; Second Medical Faculty, Charles University, Prague, Czech Republic.

Trends in Cancer
|September 1, 2023
PubMed

Insights

Type I interferon (IFN) signaling suppresses renal cancer progression. This pathway inhibits cancer cells

Area of Science:

  • Oncology
  • Immunology
  • Genetics

Background:

  • Type I interferon (IFN) plays a crucial role in cancer surveillance.
  • IFN mediates direct and immune-driven oncosuppressive effects against tumors.

Purpose of the Study:

  • To investigate the role of IFN signaling in regulating renal cancer cell adaptation to chromosomal instability (CIN).
  • To understand how IFN impacts the metastatic potential of renal cancer.

Main Methods:

  • Analysis of renal cancer cell lines.
  • Assessment of chromosomal instability (CIN) tolerance.
  • Evaluation of IFN signaling pathways.

Main Results:

  • IFN signaling negatively regulates the ability of renal cancer cells to tolerate CIN.
  • Suppressed IFN signaling correlates with enhanced tolerance to karyotypic alterations.
  • IFN pathway inhibition may promote metastatic potential in renal cancer.

Conclusions:

  • IFN signaling is a critical suppressor of renal cancer's adaptation to CIN.
  • Targeting IFN pathways could influence renal cancer progression and metastasis.
Keywords:
CGASCNVcancer stem cellscancer/immunity coevolutionimmunoevasion

More Related Videos

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.6K
Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

16.7K

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.7K