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Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice
James Z Curlin1,2, Kimberly Schmitt1, Leila Remling-Mulder1
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Journal of Medical Primatology
|September 2, 2023
Abstract:
HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4+ T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.

