Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supplementation with long-chain polyunsaturated fatty acids to extremely preterm infants associates with development of the intestinal microbiota.

Pediatric research·2026
Same author

Multiomics analyses in young grade C molar incisor pattern periodontitis.

Journal of dentistry·2026
Same author

Urea supplementation is associated with holistic changes in suprathreshold non-volatile flavour perception through oral microbiome carbon metabolism.

NPJ science of food·2026
Same author

Suprathreshold non-volatile flavour perception is associated with multiple species rather than any single species via bacterial metabolism.

Journal of oral microbiology·2026
Same author

Machine learning based multi-omics analysis reveals key molecular determinants of Parkinson's disease severity.

Neurobiology of disease·2026
Same author

Microbiome signature of Parkinson's disease in healthy and genetically at-risk individuals.

Nature medicine·2026

Related Experiment Video

Updated: Jul 17, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.7K

Leveraging circulating microbial DNA for early cancer detection.

Radhika Kataria1, Saeed Shoaie2, Anita Grigoriadis3

  • 1Cancer Bioinformatics, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK; School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Trends in Cancer
|September 2, 2023
PubMed
Summary

Microbial cell-free DNA (cfDNA) from liquid biopsies shows promise for early cancer detection by profiling the microbiome. Advanced sequencing and computational methods are key to overcoming challenges and improving diagnostic accuracy.

Keywords:
cancercirculating microbial DNAearly detectionliquid biopsymicrobiome

More Related Videos

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
08:25

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

11.1K
Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
11:11

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

16.9K

Related Experiment Videos

Last Updated: Jul 17, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.7K
Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
08:25

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

11.1K
Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
11:11

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

16.9K

Area of Science:

  • Microbiology
  • Genomics
  • Oncology

Background:

  • Microbial cell-free DNA (cfDNA) analysis presents a minimally invasive method for microbiome profiling.
  • Challenges exist in both technical and biological aspects of microbial cfDNA analysis.
  • The potential of microbial cfDNA in cancer detection is an emerging area of research.

Purpose of the Study:

  • To evaluate the potential of microbial cfDNA for early cancer detection.
  • To explore the application of deep sequencing and novel computational methods in analyzing microbial cfDNA.
  • To assess the feasibility of targeting the microbiome via liquid biopsies for improved cancer diagnostics.

Main Methods:

  • Deep sequencing techniques for comprehensive microbial cfDNA analysis.
  • Development of novel laboratory approaches for cfDNA extraction and characterization.
  • Application of advanced computational methods for microbiome profiling from cfDNA data.

Main Results:

  • Ongoing evaluation of microbial cfDNA for cancer detection.
  • Increasing use of deep sequencing and computational tools in this field.
  • Exploration of liquid biopsy-based microbiome profiling.

Conclusions:

  • Microbial cfDNA holds significant potential for minimally invasive cancer detection.
  • Overcoming technical and biological challenges is crucial for realizing this potential.
  • Liquid biopsy-based microbiome analysis could enhance early cancer detection strategies.