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Gut microbiota changes in horses with Chlamydia
Youshun Jin1,2, Wei Li1, Xuli Ba1,2
1State Key Laboratory for Animal Disease Control and Prevention, Key Laboratory of Veterinary Public Health of Agriculture Ministry Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Chlamydia infection in horses alters gut microbiota, increasing microbial diversity and changing bacterial composition. This impacts carbohydrate and amino acid metabolism, offering insights into Chlamydia-induced intestinal issues.
Area of Science:
- Veterinary Microbiology
- Equine Health
- Zoonotic Disease Research
Background:
- Zoonotic diseases, including Chlamydia infections, pose public health risks.
- Chlamydia can colonize animal intestinal tracts, altering gut microbiota.
- Limited research exists on Chlamydia's impact on equine gut microbiota.
Purpose of the Study:
- To investigate gut microbiota and serum biochemical changes in Chlamydia-infected horses.
- To compare these parameters between infected and healthy horses.
Main Methods:
- Collected fecal and blood samples from 16 horses (10 infected, 6 healthy).
- Analyzed gut microbiota composition and diversity.
- Assessed serum biochemical indicators.
Main Results:
- Chlamydia-infected horses showed increased globulin, ALT, and CK levels.
- Gut microbial diversity was higher in infected horses.
- Significant shifts in bacterial abundance (decreased Moraxellaceae, Akkermanisa; increased Streptococcus, Treponema, Prevotella, Paraprevotella).
- Altered metabolic profiles: increased carbohydrate metabolism, decreased amino acid metabolism.
- 18 bacterial genera correlated with 5 serum biochemical indicators.
Conclusions:
- Chlamydia infection significantly influences equine gut microbiota composition and metabolic functions.
- This study enhances understanding of Chlamydia-induced intestinal infections in horses.
- Findings contribute to knowledge of host-microbe interactions in Chlamydia-affected animals.
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