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Related Concept Videos

Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

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Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
302

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Related Experiment Video

Updated: Jul 17, 2025

How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project
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DaTSCAN® dilution with 0.9% NaCl - A stability evaluation.

F Avry1, O David2, N Arlicot3

  • 1CHRU de Tours, Tours, France.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|September 3, 2023
PubMed
Summary
This summary is machine-generated.

Iodine-123 ioflupane (DaTSCAN®) remains stable when diluted with saline. This finding supports its safe use and offers flexibility in preparation for brain dopamine transporter imaging.

Keywords:
(123)I-ioflupaneDaTSCAN®DilutionStability

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Area of Science:

  • Nuclear Medicine
  • Radiopharmacology
  • Neuroimaging

Background:

  • 123I-ioflupane (DaTSCAN®) is a radiopharmaceutical used to visualize brain dopamine transporter (DaT) receptor distribution.
  • Accurate DaT imaging relies on the stability of the radiopharmaceutical.

Purpose of the Study:

  • To evaluate the stability of 123I-ioflupane after dilution with 0.9% sodium chloride solution.
  • To assess the potential for using saline dilution as a method for preparing DaTSCAN®.

Main Methods:

  • 123I-ioflupane samples were prepared according to Summary of Product Characteristics recommendations.
  • Stability was assessed by measuring free 123I-iodide levels in both diluted and undiluted samples over a 1-hour period.

Main Results:

  • No significant increase in free 123I-iodide was observed in diluted 123I-ioflupane samples compared to undiluted samples.
  • The radiopharmaceutical demonstrated stability in 0.9% sodium chloride solution for up to 1 hour post-dilution.

Conclusions:

  • 123I-ioflupane exhibits stability when diluted with 0.9% sodium chloride.
  • Saline dilution is a suitable alternative method for preparing DaTSCAN® for clinical use, potentially compensating for dilution errors.