DaTSCAN® dilution with 0.9% NaCl - A stability evaluation

¹²³I-ioflupane (DaTSCAN®, GE) is a well-known ready-to-use radiopharmaceutical employed as a visualizing tool of the brain dopamine transporter receptor distribution. According to the Summary of Product Characteristics recommendations, we evaluated the stability of the DaTSCAN® after a 0.9% sodium chloride solution dilution. No significant increase in free ¹²³I-iodide was revealed between diluted and undiluted samples over a 1-h timeframe. This stability in sodium chloride can compensate for potential dilution error and offers a suitable alternative method for syringing DaTSCAN®.